Vacuolin-1
Vacuolin-1 is a potent and cell-permeable lysosomal exocytosis inhibitor. Vacuolin-1 blocks the Ca2+-dependent exocytosis of lysosomes and prevents the release of lysosomal content without affecting the process of resealing. vacuolin‐1 is a potent and selective PIKfyve inhibitor and inhibits late‐stage autophagy by impairing lysosomal maturation. Vacuolin-1 can induce vacuole formation and increase the percentage of enucleated cells[1][2][4].
Product Specifications
CAS Number
[351986-85-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; PIKfyve
Type
Reference compound
Related Pathways
Autophagy; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vacuolin-1.html
Purity
98.54
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
IC1=CC(/C=N/NC2=NC(N(C3=CC=CC=C3)C4=CC=CC=C4)=NC(N5CCOCC5)=N2)=CC=C1
Molecular Formula
C26H24IN7O
Molecular Weight
577.42
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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