(+) -Oxanthromicin
(+) -Oxanthromicin (Compound 1) mislocalizes the oncogenic mutant K-Ras from the plasma membrane of intact Madin-Darby canine kidney (MDCK) cells, and exhibits thereby antitumor efficacy[1].
Product Specifications
CAS Number
[1616622-08-2]
UNSPSC
12352005
Target
Ras
Type
Natural Products
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/plus-oxanthromicin.html
Smiles
C[C@]1(C2=CC(O)=C(C(O)=O)C(C)=C2C(C3=C(O)C(C)=CC=C31)=O)OO[C@@]4(C5=CC(O)=C(C(O)=O)C(C)=C5C(C6=C(O)C(C)=CC=C64)=O)C
Molecular Formula
C36H30O12
Molecular Weight
654.62
References & Citations
[1]Salim AA, et al., Rare Streptomyces sp. polyketides as modulators of K-Ras localisation. Org Biomol Chem. 2014 Jul 21;12 (27) :4872-8.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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