4-Aminonaphthalimide
4-Aminonaphthalimide is a potent PARP inhibitor and potentiates the cytotoxicity of γ-radiation in cancer cells[1].
Product Specifications
CAS Number
[1742-95-6]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/4-aminonaphthalimide.html
Purity
97.0
Solubility
DMSO : 1 mg/mL (ultrasonic; warming)
Smiles
O=C1NC(C2=CC=C(N)C3=CC=CC1=C23)=O
Molecular Formula
C12H8N2O2
Molecular Weight
212.21
Precautions
H315, H319, H335
References & Citations
[1]Schlicker A, et al. 4-Amino-1,8-naphthalimide: a novel inhibitor of poly (ADP-ribose) polymerase and radiation sensitizer. Int J Radiat Biol. 1999 Jan;75 (1) :91-100.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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