Methoxamine (hydrochloride)

Methoxamine hydrochloride is a selective alpha1-adrenergic receptor agonist. Methoxamine hydrochloride causes vasoconstriction and increased peripheral vascular resistance[1][2]. Methoxamine hydrochloride significantly increased the overflow of ATP, ADP and AMP, but not adenosine, by a prazosin-sensitive mechanism in the rabbit pulmonary artery[3].

Product Specifications

CAS Number

[61-16-5]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Methoxamine_hydrochloride.html

Purity

99.32

Solubility

DMSO : 135 mg/mL (ultrasonic)

Smiles

OC(C(N)C)C1=CC(OC)=CC=C1OC.[H]Cl

Molecular Formula

C11H18ClNO3

Molecular Weight

247.72

Precautions

H315, H319, H335

References & Citations

[1]Sanders AB. The roles of methoxamine and norepinephrine in electromechanical dissociation. Ann Emerg Med. 1984;13 (9 Pt 2) :835-839. |[2]Chang KC. Hypertensive effects of methoxamine on arterial mechanics in rats: analysis based on exponentially tapered T-tube model. Eur J Pharmacol. 1998;350 (2-3) :195-202.|[3]Takeuchi K, et al. Methoxamine-induced release of endogenous ATP from rabbit pulmonary artery. Eur J Pharmacol. 1994;254 (3) :287-290.