Resatorvid

[1]Ii M, et al. A novel cyclohexene derivative, ethyl (6R) -6-[N- (2-Chloro-4-fluorophenyl) sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling.|[2]Yamada M, et al. Discovery of novel and potent small-molecule inhibitors of NO and cytokine production as antisepsis agents: synthesis and biological activity of alkyl 6- (N-substituted sulfamoyl) cyclohex-1-ene-1-carboxylate. J Med Chem. 2005 Nov 17;48 (23) :7457-67.|[3]Yuko Ono, et al. TAK-242, a Specific Inhibitor of Toll-like Receptor 4 Signalling, Prevents Endotoxemia-Induced Skeletal Muscle Wasting in Mice. Sci Rep. 2020 Jan 20;10 (1) :694.