Native Human Proteinase 3

<strong>Native Human Proteinase 3</strong>_x000D_ <strong>Catalog number:</strong> B2018768_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 2 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> N/A_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> 2-8¬∞C_x000D_ <strong>Keywords:</strong> ACPA, AGP7, C-ANCA, CANCA, MBN, MBT, NP-4, NP4, P29, PR-3, PR3_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MŒ©-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Surmiak M, Kaczor M, Sanak M. Proinflammatory genes expression in granulocytes activated by native proteinase-binding fragments of anti-proteinase 3 IgG J Physiol Pharmacol. 2015 Aug;66(4):609-15._x000D_ 2: Damoiseaux J, D√§hnrich C, Rosemann A, Probst C, Komorowski L, Stegeman CA, Egerer K, Hiepe F, van Paassen P, St√∂cker W, Schlumberger W, Tervaert JW. A novel enzyme-linked immunosorbent assay using a mixture of human native and recombinant proteinase-3 significantly improves the diagnostic potential for antineutrophil cytoplasmic antibody-associated vasculitis Ann Rheum Dis. 2009 Feb;68(2):228-33._x000D_ 3: Khorsand F, Haug BE, Kursula I, Reuter N, Brenk R. Expression and purification of human neutrophil proteinase 3 from insect cells and characterization of ligand binding PLoS One. 2024 Jun 25;19(6):e0294827._x000D_ 4: Traum A, Hofmann C, Haas S, Schmidt S, Bein G, Sachs UJ, Bayat B. Characterization of CD177-reactive iso- and auto-antibodies Transfusion. 2021 Jun;61(6):1916-1922._x000D_ 5: Jenne DE, Kuhl A. Production and applications of recombinant proteinase 3, Wegener's autoantigen: problems and perspectives Clin Nephrol. 2006 Sep;66(3):153-9._x000D_ 6: Relle M, Mayet WJ, Strand D, Brenner W, Galle PR, Schwarting A. Proteinase 3/myeloblastin as a growth factor in human kidney cells J Nephrol. 2003 Nov-Dec;16(6):831-40._x000D_ 7: Tongaonkar P, Golji AE, Tran P, Ouellette AJ, Selsted ME. High fidelity processing and activation of the human Œ±-defensin HNP1 precursor by neutrophil elastase and proteinase 3 PLoS One. 2012;7(3):e32469._x000D_ 8: Zoega M, Trier NH, Nejrup RG, Chailyan A, Friis T, H√∏jrup P, Houen G. Defensin Interactions in Relation to Monoclonal and Disease-Related Proteinase 3 Antibodies Binding at the Catalytic Site Antibodies (Basel). 2023 Mar 13;12(1):23._x000D_ 9: Zhou Z, Richard C, M√©nard HA. De novo synthesis of proteinase 3 by cytokine primed circulating human polymorphonuclear neutrophils and mononuclear cells J Rheumatol. 2000 Oct;27(10):2406-11._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/8100709">10: Rao NV, Marshall BC, Gray BH, Hoidal JR. Interaction of secretory leukocyte protease inhibitor with proteinase-3 Am J Respir Cell Mol Biol. 1993 Jun;8(6):612-6. </a>_x000D_ _x000D_ <strong>Products Related to Native Human Proteinase 3 can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>