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TBAP-001

TBAP-001 (Synthesis 13), extracted from patent WO2015075483A1, is a pan-RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay[1].

Product Specifications

CAS Number

1777832-90-2

UNSPSC

12352005

Target

Raf

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tbap-001.html

Concentration

10mM

Purity

99.81

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC(C(C)(C)C)=NN1C2=CC=CC(F)=C2)NC3=CC=C(OC4=C(N=C5)C(NC5=O)=NC=C4)C=C3F

Molecular Formula

C27H23F2N7O3

Molecular Weight

531.51

References & Citations

[1]Caroline Joy, et al. 1 - (5-TERT-BUTYL-2-ARYL-PYRAZOL-3-YL) -3-[2-FLUORO-4-[ (3-OXO-4H-PYRIDO[2

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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