Gcase activator 2
Gcase activator 2 (compound 14), a pyrrolo[2,3-b]pyrazine, is alos a β-Glucocerebrosidase (GCase) activator (EC50=3.8 μM) . Gcase activator 2 induces GCase dimerizatio (both K-type and V-type) . And Gcase activator 2 has low metabolic clearance in human and mouse[1].
Product Specifications
CAS Number
2759897-35-1
UNSPSC
12352005
Target
Glycosidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/gcase-activator-2.html
Concentration
10mM
Purity
99.23
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(N1CCC(C2=CC3=NC(C4=CC=C(OC)C=C4)=CN=C3N2C)CC1)=O
Molecular Formula
C21H24N4O2
Molecular Weight
364.44
References & Citations
[1]Benz J, et al. Novel β-Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization. Angew Chem Int Ed Engl. 2021 Mar 1;60 (10) :5436-5442. |[2]Benz J, et al. Novel β-Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization. Angew Chem Int Ed Engl. 2021 Mar 1;60 (10) :5436-5442.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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