Gcase activator 2

Gcase activator 2 (compound 14), a pyrrolo[2,3-b]pyrazine, is alos a β-Glucocerebrosidase (GCase) activator (EC50=3.8 μM) . Gcase activator 2 induces GCase dimerizatio (both K-type and V-type) . And Gcase activator 2 has low metabolic clearance in human and mouse[1].

Product Specifications

CAS Number

[2759897-35-1]

UNSPSC

12352005

Target

Glycosidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/gcase-activator-2.html

Concentration

10mM

Purity

99.23

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(N1CCC(C2=CC3=NC(C4=CC=C(OC)C=C4)=CN=C3N2C)CC1)=O

Molecular Formula

C21H24N4O2

Molecular Weight

364.44

References & Citations

[1]Benz J, et al. Novel β-Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization. Angew Chem Int Ed Engl. 2021 Mar 1;60 (10) :5436-5442. |[2]Benz J, et al. Novel β-Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization. Angew Chem Int Ed Engl. 2021 Mar 1;60 (10) :5436-5442.