BAY-678

BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC) .

Product Specifications

CAS Number

[675103-36-3]

UNSPSC

12352005

Target

Elastase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/BAY-678.html

Concentration

10mM

Purity

99.59

Solubility

DMSO : ≥ 100 mg/mL|Ethanol : ≥ 4.76 mg/mL

Smiles

N#CC1=NC=C([C@H](C(C(C)=O)=C(C)N2C3=CC=CC(C(F)(F)F)=C3)NC2=O)C=C1

Molecular Formula

C20H15F3N4O2

Molecular Weight

400.35

References & Citations

[1]von Nussbaum F, et al. Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases. ChemMedChem. 2015 Jul;10 (7) :1163-73.|[2]von Nussbaum F, et al. Neutrophil elastase inhibitors for the treatment of (cardio) pulmonary diseases: Into clinical testing with pre-adaptive pharmacophores. Bioorg Med Chem Lett. 2015 Oct 15;25 (20) :4370-81.|[3]BAY-678 Selective chemical probe for Human Neutrophil Elastase.