(±) -Nornicotine

(±) -Nornicotine is a major metabolite of Nicotine. (±) -Nornicotine is a partial nAChRs agonist, specifically activating receptor subtypes containing α7 and α6 subunits. (±) -Nornicotine disrupts β-catenin and ZO-1, and induces F-actin depolymerization. (±) -Nornicotine supports self-administration behavior. (±) -Nornicotine can be used in the research of atherosclerosis, Alzheimer's disease, and schizophrenia[1][2][3][4].

Product Specifications

CAS Number

[5746-86-1]

Product Name Alternative

Nornicotine

UNSPSC

12352005

Hazard Statement

H301, H311, H315, H319, H331, H335

Target

Drug Metabolite; Endogenous Metabolite; nAChR; β-catenin

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Stem Cell/Wnt

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/racemic-nornicotine.html

Purity

98.84

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C1(C2NCCC2)=CC=CN=C1

Molecular Formula

C9H12N2

Molecular Weight

148.20

Precautions

H301, H311, H315, H319, H331, H335

References & Citations

[1]Papke RL, et al. The pharmacological activity of nicotine and nornicotine on nAChRs subtypes: relevance to nicotine dependence and drug discovery. J Neurochem. 2007 Apr;101 (1) :160-7.|[2]Gagat M, et al. Nornicotine impairs endothelial cell-cell adherens junction complexes in EA.hy926 cell line via structural reorganization of F-actin. Folia Histochem Cytobiol. 2013;51 (3) :179-92.|[3]Bardo MT, et al. Nornicotine is self-administered intravenously by rats. Psychopharmacology (Berl) . 1999 Oct;146 (3) :290-6.|[4]Hoffman AC, et al. Abuse potential of non-nicotine tobacco smoke components: acetaldehyde, nornicotine, cotinine, and anabasine. Nicotine Tob Res. 2013 Mar;15 (3) :622-32.