PD 407824

PD 407824 is a checkpoint kinase Chk1 and WEE1 inhibitor with IC50s of 47 and 97 nM, respectively. PD 407824 is a chemical BMP sensitizer and increases the sensitivity of cells to sub-threshold amounts of BMP4[1][2].

Product Specifications

CAS Number

[622864-54-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Checkpoint Kinase (Chk) ; Wee1

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pd-407824.html

Purity

99.00

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C1NC(C2=C1C3=C(C=C2C4=CC=CC=C4)NC5=C3C=C(O)C=C5)=O

Molecular Formula

C20H12N2O3

Molecular Weight

328.32

Precautions

H302, H315, H319, H335

References & Citations

[1]Palmer BD, et al. 4-Phenylpyrrolo[3,4-c]carbazole-1,3 (2H,6H) -dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitution. J Med Chem. 2006 Aug 10;49 (16) :4896-911.|[2]Feng L, et al. Discovery of a Small-Molecule BMP Sensitizer for Human Embryonic Stem Cell Differentiation. Cell Rep. 2016 May 31;15 (9) :2063-75.|[3]Smaill JB, et al. Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3 (2H,6H) -diones as inhibitors of Wee1 and Chk1 checkpointkinases. Eur J Med Chem. 2008 Jun;43 (6) :1276-96. Epub 2007 Aug 6.