2,3-Diphospho-D-glyceric acid (pentasodium salt)

2,3-Diphospho-D-glyceric acid pentasodium salt is a highly anionic polyphosphorus compound. 2,3-Diphospho-D-glyceric acid is present in the concave center of red blood cells, it binds hemoglobin to reduce its oxygen affinity. 2,3-Diphospho-D-glyceric acid is an endogenous, selective inhibitor of vascular calcification (VC) and significantly delays the formation of crystalline calpain particles (CPP) . 2,3-Diphospho-D-glyceric acid also inhibits calcification in mouse vascular smooth muscle cell line (MOVAS) without cytotoxic effects[1].

Product Specifications

CAS Number

[102783-53-9]

Product Name Alternative

2,3-DPG (pentasodium salt)

UNSPSC

12352211

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/2-3-diphospho-d-glyceric-acid-pentasodium-salt.html

Purity

95.0

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

O=P(O[Na])(O[Na])OC[C@H](C(O[Na])=O)OP(O[Na])(O[Na])=O

Molecular Formula

C3H3Na5O10P2

Molecular Weight

375.95

References & Citations

[1]Kharaghani D, Kohno S, Minamizaki T, et al. 2, 3-Diphospho-D-glyceric acid inhibits calciprotein particle growth and calcification in MOVAS cells but not in MC3T3-E1 cells[J]. Colloid and Interface Science Communications, 2022, 50: 100668.