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XR8-89

XR8-89 is a potent papain-like protease (PLpro) inhibitor with an IC50 value of 0.1 μM. XR8-89 induces conformational changes in SARS-COV-2 papain-like protease, inhibiting SARS-CoV-2 replication. XR8-89 can be used for SARS-CoV-2 research[1].

Product Specifications

CAS Number

2817811-16-6

UNSPSC

12352005

Target

SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/xr8-89.html

Purity

97.41

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC1=CC=C(NC2CNC2)C=C1C(N[C@H](C)C3=CC=CC(C4=CC=C(S4)CN[C@@H]5C[C@H](O)CC5)=C3)=O

Molecular Formula

C29H36N4O2S

Molecular Weight

504.69

References & Citations

[1]Ferreira GM, et, al. Inhibitor induced conformational changes in SARS-COV-2 papain-like protease. Sci Rep. 2022 Jul 8;12 (1) :11585.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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