XR8-89
XR8-89 is a potent papain-like protease (PLpro) inhibitor with an IC50 value of 0.1 μM. XR8-89 induces conformational changes in SARS-COV-2 papain-like protease, inhibiting SARS-CoV-2 replication. XR8-89 can be used for SARS-CoV-2 research[1].
Product Specifications
CAS Number
2817811-16-6
UNSPSC
12352005
Target
SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/xr8-89.html
Purity
97.41
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC1=CC=C(NC2CNC2)C=C1C(N[C@H](C)C3=CC=CC(C4=CC=C(S4)CN[C@@H]5C[C@H](O)CC5)=C3)=O
Molecular Formula
C29H36N4O2S
Molecular Weight
504.69
References & Citations
[1]Ferreira GM, et, al. Inhibitor induced conformational changes in SARS-COV-2 papain-like protease. Sci Rep. 2022 Jul 8;12 (1) :11585.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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