FITC-Dextran (MW 3000-5000)

FITC-Dextran (MW 3000-5000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm) . FITC-Dextran (MW 3000-5000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 3000-5000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption[1][2][3]. Storage: protect from light.

Product Specifications

CAS Number

[60842-46-8]

UNSPSC

12171500

Hazard Statement

H315, H319, H335

Target

Biochemical Assay Reagents

Type

Dye Reagents

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/fitc-dextran-mw-3000-5000.html

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

[FITC-Dextran(MW3000-5000)]

Molecular Weight

3000-5000 (Average)

Precautions

H315, H319, H335

References & Citations

[1]Moumaris M, et al. Fluorescein isothiocyanate-dextran can track apoptosis and necrosis induced by heat shock of peripheral blood mononuclear cells and HeLa cells[J]. Open Biological Sciences Journal, 2015, 1 (1) .|[2]Natarajan R, et al. Fluorescein Isothiocyanate (FITC) -Dextran Extravasation as a Measure of Blood-Brain Barrier Permeability. Curr Protoc Neurosci. 2017 Apr 10;79:9.58.1-9.58.15.|[3]Eriksson I, et al. Analysis of Lysosomal pH by Flow Cytometry Using FITC-Dextran Loaded Cells. Methods Mol Biol. 2017;1594:179-189.|[4]Okabayashi K, et al. Cdc42 activates paracellular transport in polarised submandibular gland cells. Arch Oral Biol. 2021 Dec;132:105276.|[5]Yu W, et al. ACE2 contributes to the maintenance of mouse epithelial barrier function. Biochem Biophys Res Commun. 2020 Dec 17;533 (4) :1276-1282.