ARUK3001185
ARUK3001185 is a potent, selective, orally active and brain-penetrant inhibitor of Notum (IC50 = 6.7 nM) . ARUK3001185 can restore Wnt signaling in the presence of Notum in vitro. ARUK3001185 is selective against serine hydrolases, kinases, and drug targets. ARUK3001185 can be used to research the role of Notum plays in diseases[1].
Product Specifications
CAS Number
[2411969-39-4]
UNSPSC
12352005
Target
Wnt
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/aruk3001185.html
Concentration
10mM
Purity
99.28
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(F)(C1=C(Cl)C=CC(N2C=CN=N2)=C1Cl)F
Molecular Formula
C9H4Cl2F3N3
Molecular Weight
282.05
References & Citations
[1]Willis NJ, et al. Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit. J Med Chem. 2022 May 26;65 (10) :7212-7230.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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