Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc
Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc incorporates the Thalidomide based cereblon ligand and a linker. Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc can be used for the synthesis of PROTAC BET degrader[1]. (From patent WO2017180417A1 compound s7) .
Product Specifications
CAS Number
[1799711-31-1]
UNSPSC
12352005
Target
Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thalidomide-o-amido-ch2-peg3-ch2-nh-boc.html
Purity
98.43
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NCCCOCCOCCOCCCNC(COC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O)=O)OC(C)(C)C
Molecular Formula
C30H42N4O11
Molecular Weight
634.67
References & Citations
[1]Shaomeng Wang, et al. Bet protein degraders. WO2017180417A1.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
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