ML402
ML402, a thiophene-carboxamide, is a selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator. ML402 is inactive against K2P4.1 (TRAAK) [1].
Product Specifications
CAS Number
[298684-44-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ML402.html
Purity
99.42
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(C1=CC=CS1)NCCOC2=CC=C(Cl)C=C2C
Molecular Formula
C14H14ClNO2S
Molecular Weight
295.78
Precautions
H302, H315, H319, H335
References & Citations
[1]Lolicato M, et al. K2P2.1 (TREK-1) -activator complexes reveal a cryptic selectivity filter binding site. Nature. 2017 Jul 20;547 (7663) :364-368.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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