Pomalidomide-C12-NH2 (hydrochloride)

Pomalidomide-C12-NH2 hydrochloride is the E3 ligase ligand-linker conjugate of PROTAC KRAS G12C degrader-1 (HY-139186) . PROTAC KRAS G12C degrader-1 is a Cereblon-based KRASG12C degrader[1].

Product Specifications

CAS Number

[2862774-02-3]

UNSPSC

12352005

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pomalidomide-c12-nh2-hydrochloride.html

Purity

97.09

Solubility

10 mM in DMSO

Smiles

NCCCCCCCCCCCCNC1=C(C(N(C2CCC(NC2=O)=O)C3=O)=O)C3=CC=C1.Cl

Molecular Formula

C25H37ClN4O4

Molecular Weight

493.04

References & Citations

[1]Zeng M, et, al. Exploring Targeted Degradation Strategy for Oncogenic KRAS G12C. Cell Chem Biol. 2020 Jan 16;27 (1) :19-31.e6.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Cereblon

Available Sizes

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