Pomalidomide-C12-NH2 (hydrochloride)

Pomalidomide-C12-NH2 hydrochloride is the E3 ligase ligand-linker conjugate of PROTAC KRAS G12C degrader-1 (HY-139186) . PROTAC KRAS G12C degrader-1 is a Cereblon-based KRASG12C degrader[1].

Product Specifications

CAS Number

[2862774-02-3]

UNSPSC

12352005

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pomalidomide-c12-nh2-hydrochloride.html

Purity

97.09

Solubility

10 mM in DMSO

Smiles

NCCCCCCCCCCCCNC1=C(C(N(C2CCC(NC2=O)=O)C3=O)=O)C3=CC=C1.Cl

Molecular Formula

C25H37ClN4O4

Molecular Weight

493.04

References & Citations

[1]Zeng M, et, al. Exploring Targeted Degradation Strategy for Oncogenic KRAS G12C. Cell Chem Biol. 2020 Jan 16;27 (1) :19-31.e6.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Cereblon

Available Sizes

More Discoveries

Explore Other Products

Browse additional items from our catalog

30635101-2 100 g

CSM-Ade-His-Trp Powder, 100 grams

View Details

E51K2923 40 µL

Carbonyl Reductase 1 Rabbit Monoclonal Antibody [KD Validation]

View Details

sc-97270-V 200 µL

EGFL4 shRNA (h) Lentiviral Particles

View Details

DF3791-BP 1 mg

ARG1 Peptide

View Details

JOT20085F 25μg

PerCP Anti-Mouse CD11c Antibody

View Details

50371121 3x 1.0µg DNA

WDR8 CRISPRa sgRNA lentivector (set of three targets)(Human)

View Details