Pomalidomide-C12-NH2 (hydrochloride)
Pomalidomide-C12-NH2 hydrochloride is the E3 ligase ligand-linker conjugate of PROTAC KRAS G12C degrader-1 (HY-139186) . PROTAC KRAS G12C degrader-1 is a Cereblon-based KRASG12C degrader[1].
Product Specifications
CAS Number
[2862774-02-3]
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pomalidomide-c12-nh2-hydrochloride.html
Purity
97.09
Solubility
10 mM in DMSO
Smiles
NCCCCCCCCCCCCNC1=C(C(N(C2CCC(NC2=O)=O)C3=O)=O)C3=CC=C1.Cl
Molecular Formula
C25H37ClN4O4
Molecular Weight
493.04
References & Citations
[1]Zeng M, et, al. Exploring Targeted Degradation Strategy for Oncogenic KRAS G12C. Cell Chem Biol. 2020 Jan 16;27 (1) :19-31.e6.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
252455 100 µg
TCEA3 (Transcription Elongation Factor A (SII), 3, TFIIS, TFIIS.H)
Sign In for Pricing
View Details 
GPC2165-5Y 5 Kg
Tri Potassium Citrate 99-100.5% Monohydrate Food Grade
Sign In for Pricing
View Details 