TDP1 Inhibitor-1
TDP1 Inhibitor-1 is a potent Tyrosyl-DNA Phosphodiesterase 1 (TDP1) inhibitor with an IC50 of 7 μM. TDP1 Inhibitor-1 shows cytotoxicity against multiple cancer cells. TDP1 Inhibitor-1 can be used for the research of cancer, such as breast cancer[1].
Product Specifications
CAS Number
2248702-80-7
Product Name Alternative
K03859
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tdp1-inhibitor-1.html
Purity
98.33
Solubility
DMSO : 3.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
COC1=C(OC)C=C(C(OCCN2CCCC2)=NC3=C4C=CC5=CC6=C(OCO6)C=C35)C4=C1
Molecular Formula
C26H26N2O5
Molecular Weight
446.50
References & Citations
[1]Zhang XR, et al. Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents. J Med Chem. 2018 Nov 21;61 (22) :9908-9930.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC040304-100 1x 100 µL
CD106 / VCAM1 (B-K9), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC741081-100 1x 100 µL
CD45RO (190-2F2.5), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC680890-500 1x 500 µL
NGFR (Nerve Growth Factor Receptor) (NGFR5), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC470296-100 1x 100 µL
Blood Group Antigen B (CD173) (HEB-20), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC942460-100 1x 100 µL
Cyclin E (G1/S-Phase Cyclin) (CCNE1/2460), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details