TDP1 Inhibitor-1

TDP1 Inhibitor-1 is a potent Tyrosyl-DNA Phosphodiesterase 1 (TDP1) inhibitor with an IC50 of 7 μM. TDP1 Inhibitor-1 shows cytotoxicity against multiple cancer cells. TDP1 Inhibitor-1 can be used for the research of cancer, such as breast cancer[1].

Product Specifications

CAS Number

[2248702-80-7]

Product Name Alternative

K03859

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tdp1-inhibitor-1.html

Purity

98.33

Solubility

DMSO : 3.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

COC1=C(OC)C=C(C(OCCN2CCCC2)=NC3=C4C=CC5=CC6=C(OCO6)C=C35)C4=C1

Molecular Formula

C26H26N2O5

Molecular Weight

446.50

References & Citations

[1]Zhang XR, et al. Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents. J Med Chem. 2018 Nov 21;61 (22) :9908-9930.