TAO Kinase inhibitor 1
TAO Kinase inhibitor 1 (compound 43) is a selective, ATP-competitive thousand-and-one amino acid kinases (TAOK) inhibitor with IC50s of 11 to 15 nM for TAOK1 and 2, respectively. TAO Kinase inhibitor 1 delays mitosis and induces mitotic cell death[1].
Product Specifications
CAS Number
[850467-66-2]
Product Name Alternative
CP 43
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MAP3K; Mitosis
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tao-kinase-inhibitor-1.html
Purity
99.81
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
O=C(CNC(C1=CC=C(C2=CC=CC=C2)C=C1)=O)NC(CCC3)C4=C3C=CC=C4
Molecular Formula
C25H24N2O2
Molecular Weight
384.47
Precautions
H302, H315, H319, H335
References & Citations
[1]Koo CY, et al. Targeting TAO Kinases Using a New Inhibitor Compound Delays Mitosis and Induces Mitotic Cell Death in Centrosome Amplified Breast Cancer Cells. Mol Cancer Ther. 2017 Nov;16 (11) :2410-2421.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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