10-DEBC (hydrochloride)
10-DEBC hydrochloride is a selective Akt inhibitor, with an IC50 of 1.28 μM. 10-DEBC hydrochloride is a novel anti-TB compound[1][2].
Product Specifications
CAS Number
925681-41-0
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Akt; Bacterial
Type
Reference compound
Related Pathways
Anti-infection; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/10-debc-hydrochloride.html
Purity
99.82
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)
Smiles
CCN(CC)CCCCN1C2=C(C=CC=C2)OC3=CC=C(Cl)C=C13.[H]Cl
Molecular Formula
C20H26Cl2N2O
Molecular Weight
381.34
Precautions
H315, H319, H335
References & Citations
[1]Wei Li, et al. More than just a GPCR ligand: structure-based discovery of thioridazine derivatives as Pim-1 kinase inhibitors. Medicinal Chemistry Communications.|[2]Hyo-Won Han, et al. Drug Discovery Platform Targeting M. tuberculosis with Human Embryonic Stem Cell-Derived Macrophages. Stem Cell Reports. 2019 Dec 10;13 (6) :980-991.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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