10-DEBC (hydrochloride)

10-DEBC hydrochloride is a selective Akt inhibitor, with an IC50 of 1.28 μM. 10-DEBC hydrochloride is a novel anti-TB compound[1][2].

Product Specifications

CAS Number

[925681-41-0]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Akt; Bacterial

Type

Reference compound

Related Pathways

Anti-infection; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/10-debc-hydrochloride.html

Purity

99.82

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

CCN(CC)CCCCN1C2=C(C=CC=C2)OC3=CC=C(Cl)C=C13.[H]Cl

Molecular Formula

C20H26Cl2N2O

Molecular Weight

381.34

Precautions

H315, H319, H335

References & Citations

[1]Wei Li, et al. More than just a GPCR ligand: structure-based discovery of thioridazine derivatives as Pim-1 kinase inhibitors. Medicinal Chemistry Communications.|[2]Hyo-Won Han, et al. Drug Discovery Platform Targeting M. tuberculosis with Human Embryonic Stem Cell-Derived Macrophages. Stem Cell Reports. 2019 Dec 10;13 (6) :980-991.