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(3S,4S) -Tivantinib

(3S,4S) -Tivantinib is a potent and highly selective inhibitor of the receptor tyrosine kinase c-MET. (3S,4S) -Tivantinib has two novel targets, GSK3α and GSK3β, which play an important role in the cellular mechanism of non-small cell lung cancer (NSCLC) [1].

Product Specifications

CAS Number

[905854-03-7]

Product Name Alternative

(3S,4S) -ARQ 197; ARQ 198

UNSPSC

12352005

Hazard Statement

H302, H315, H320, H335

Target

C-Met/HGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/3s-4s-tivantinib.html

Purity

98.71

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C(N1)[C@@H]([C@H](C1=O)C2=CNC3=C2C=CC=C3)C4=CN5CCCC6=C5C4=CC=C6

Molecular Formula

C23H19N3O2

Molecular Weight

369.42

Precautions

H302, H315, H320, H335

References & Citations

[1]Remsing Rix LL, et al. GSK3 alpha and beta are new functionally relevant targets of tivantinib in lung cancer cells. ACS Chem Biol. 2014 Feb 21;9 (2) :353-8.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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