Oltipraz (GMP)
Oltipraz (GMP) is Oltipraz produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Oltipraz has an inhibitory effect on HIF-1α activation. Oltipraz is a potent Nrf2 activator[1][2].
Product Specifications
CAS Number
64224-21-1
Product Name Alternative
RP 35972 (GMP) ; NSC 347901 (GMP)
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase; HIV; Keap1-Nrf2; Parasite
Type
GMP Small Molecules
Related Pathways
Anti-infection; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/oltipraz-gmp.html
Smiles
S=C1SSC(C2=NC=CN=C2)=C1C
Molecular Formula
C8H6N2S3
Molecular Weight
226.34
References & Citations
[1]Lee WH, et al. Oltipraz and dithiolethione congeners inhibit hypoxia-inducible factor-1alpha activity through p70 ribosomal S6 kinase-1 inhibition and H2O2-scavenging effect. Mol Cancer Ther. 2009 Oct;8 (10) :2791-802.|[2]Eba S, et al.The nuclear factor erythroid 2-related factor 2 activator oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice.Am J Respir Cell Mol Biol. 2013 Aug;49 (2) :324-33.
Shipping Conditions
Room temperature
Scientific Category
GMP Small Molecules
Clinical Information
No Development Reported
Frequently Asked Questions
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