TCS PIM-1 1
TCS PIM-1 1 (SC 204330) is a potent, selective and ATP-competitive Pim-1 kianse inhibitor with an IC50 of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2 (IC50s >20000 nM) [1].
Product Specifications
CAS Number
[491871-58-0]
Product Name Alternative
SC 204330
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Pim
Type
Reference compound
Related Pathways
JAK/STAT Signaling
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/TCS-PIM-1-1.html
Purity
98.40
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=C(C(N2)=CC(C3=CC=CC=C3)=C(C#N)C2=O)C=C(Br)C=C1
Molecular Formula
C18H11BrN2O2
Molecular Weight
367.20
Precautions
H302, H315, H319, H335
References & Citations
[1]Cheney IW, et al. Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase. Bioorg Med Chem Lett. 2007 Mar 15;17 (6) :1679-83.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PIM1
Available Sizes
Curated Selection
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