FMOC-3-azido-D-alanine

FMOC-3-azido-D-alanine is a click chemistry reagent containing an azide group[1]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

[1016163-79-3]

UNSPSC

12352005

Hazard Statement

H301-H311-H331-H341

Target

ADC Linker

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/fmoc-3-azido-d-alanine.html

Solubility

10 mM in DMSO

Smiles

O=C(O)[C@@H](CN=[N+]=[N-])NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O

Molecular Formula

C18H16N4O4

Molecular Weight

352.34

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P403+P233-P405-P501

References & Citations

[1]Millward SW, et, al. Iterative in situ click chemistry assembles a branched capture agent and allosteric inhibitor for Akt1. J Am Chem Soc. 2011 Nov 16;133 (45) :18280-8.