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ARN 077

ARN 077 is a potent and selective N-acylethanolamine acid amidase (NAAA) inhibitor with an IC50 of 7 nM for human NAAA[1]. ARN 077 significantly increases palmitoyl ethanolamine (PEA) levels within the CNS and has broad antinociceptive activity in mice and rats[2].

Product Specifications

CAS Number

1373625-34-3

Product Name Alternative

URB913

UNSPSC

12352005

Target

Ceramidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ARN_077.html

Purity

98.83

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(OCCCCCC1=CC=CC=C1)N[C@@H]2[C@H](C)OC2=O

Molecular Formula

C16H21NO4

Molecular Weight

291.34

References & Citations

[1]Sasso O, et al. Antinociceptive effects of the N-acylethanolamine acid amidase inhibitor ARN077 in rodent pain models. Pain. 2013 Mar;154 (3) :350-60.|[2]Davis MP, et al. Cannabinoids in pain management: CB1, CB2 and non-classic receptor ligands. Expert Opin Investig Drugs. 2014 Aug;23 (8) :1123-40.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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