ARN 077
ARN 077 is a potent and selective N-acylethanolamine acid amidase (NAAA) inhibitor with an IC50 of 7 nM for human NAAA[1]. ARN 077 significantly increases palmitoyl ethanolamine (PEA) levels within the CNS and has broad antinociceptive activity in mice and rats[2].
Product Specifications
CAS Number
[1373625-34-3]
Product Name Alternative
URB913
UNSPSC
12352005
Target
Ceramidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ARN_077.html
Purity
98.83
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(OCCCCCC1=CC=CC=C1)N[C@@H]2[C@H](C)OC2=O
Molecular Formula
C16H21NO4
Molecular Weight
291.34
References & Citations
[1]Sasso O, et al. Antinociceptive effects of the N-acylethanolamine acid amidase inhibitor ARN077 in rodent pain models. Pain. 2013 Mar;154 (3) :350-60.|[2]Davis MP, et al. Cannabinoids in pain management: CB1, CB2 and non-classic receptor ligands. Expert Opin Investig Drugs. 2014 Aug;23 (8) :1123-40.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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