Gü2602
Gü2602 is a potent, reversible cathepsin K (CatK) inhibitor with a Ki of 0.013 nM for mature CatK (mCatK) . Gü2602 suppresses the autocatalytic activation of the cathepsin K zymogen[1].
Product Specifications
CAS Number
1627094-88-5
UNSPSC
12352005
Target
Cathepsin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/g-2602.html
Purity
98.13
Solubility
DMSO : 66.67 mg/mL (ultrasonic)
Smiles
CN(C(CN(NC(OC(C)(C)C)=O)C#N)=O)CC1=CC=CC=C1
Molecular Formula
C16H22N4O3
Molecular Weight
318.37
References & Citations
[1]Benýšek J, et al. Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes. J Enzyme Inhib Med Chem. 2022 Dec;37 (1) :515-526.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cathepsin K
Available Sizes
Frequently Asked Questions
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