Gü2602

Gü2602 is a potent, reversible cathepsin K (CatK) inhibitor with a Ki of 0.013 nM for mature CatK (mCatK) . Gü2602 suppresses the autocatalytic activation of the cathepsin K zymogen[1].

Product Specifications

CAS Number

[1627094-88-5]

UNSPSC

12352005

Target

Cathepsin

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/g-2602.html

Purity

98.13

Solubility

DMSO : 66.67 mg/mL (ultrasonic)

Smiles

CN(C(CN(NC(OC(C)(C)C)=O)C#N)=O)CC1=CC=CC=C1

Molecular Formula

C16H22N4O3

Molecular Weight

318.37

References & Citations

[1]Benýšek J, et al. Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes. J Enzyme Inhib Med Chem. 2022 Dec;37 (1) :515-526.