Lactic acid (calcium)

Lactic acid (DL-Lactic acid) calcium is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid calcium is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid calcium is an oncometabolite and has immune protective role of lactate in anti-tumor immunity[1][2]. Lactic acid calcium also has antimicrobial activity, which can be used as a food preservative[3].

Product Specifications

CAS Number

[814-80-2]

Product Name Alternative

DL-Lactic acid (calcium) ; E-270 (calcium)

UNSPSC

12352300

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; Endogenous Metabolite; Hydroxycarboxylic Acid Receptor (HCAR)

Type

Reference compound

Related Pathways

Anti-infection; GPCR/G Protein; Metabolic Enzyme/Protease

Field of Research

Cancer; Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/lactate-calcium.html

Concentration

10mM

Purity

99.8

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL

Smiles

CC(O)C([O-])=O.[1/2].[Ca+2]

Molecular Formula

C3H6O3.1/2Ca

Molecular Weight

110.12

Precautions

H302, H315, H319, H335

References & Citations

[1]Lucia Longhitano, et al. Lactate Rewrites the Metabolic Reprogramming of Uveal Melanoma Cells and Induces Quiescence Phenotype. Int J Mol Sci. 2022 Dec 20;24 (1) :24.|[2]Qiang Feng, et al. Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity. Nat Commun. 2022 Sep 6;13 (1) :4981. |[3]Sallam KI. Antimicrobial and antioxidant effects of sodium acetate, sodium lactate, and sodium citrate in refrigerated sliced salmon. Food Control. 2007 May;18 (5) :566-575.