RORγt agonist 3
RORγt agonist 3 is a potent agonist of RORγt. RORγt agonist 3 promotes the differentiation of Th17 cells and enhances the levels of pro-inflammatory cytokines, thereby increasing the cytotoxicity of lymphocytes. RORγt agonist 3 inhibits the production of regulatory T cells, which suppresses the immune response (extracted from patent WO2021136326A1, compound 23) [1].
Product Specifications
CAS Number
[2664106-24-3]
UNSPSC
12352005
Target
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/rorγt-agonist-3.html
Purity
98.12
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#CC[C@@H](C1=CC=C(C=C1)S(CC)(=O)=O)NC(C(C=C2)=CC=C2N(C3=CC(C4CC4)=CC(C5CC5)=C3)CC6CC6)=O
Molecular Formula
C34H37N3O3S
Molecular Weight
567.74
References & Citations
[1]Liu Bin, et al. Aromatic amides and their use in pharmaceuticals. Patent WO2021136326A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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