Intepirdine
Intepirdine (SB742457) is a highly selective 5-HT6 receptor antagonist with pKi of 9.63; exhibits >100-fold selectivity over other receptors.
Product Specifications
CAS Number
607742-69-8
Product Name Alternative
SB-742457; GSK-742457; RVT-101
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/SB-742457.html
Purity
98.92
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=CC=C1)(C2=CC(C=CC=C3N4CCNCC4)=C3N=C2)=O
Molecular Formula
C19H19N3O2S
Molecular Weight
353.44
Precautions
H302, H315, H319, H335
References & Citations
[1]Callaghan CK, Hok V, Della-Chiesa A, et al. Age-related declines in delayed non-match-to-sample performance (DNMS) are reversed by the novel 5HT6 receptor antagonist SB742457. Neuropharmacology. 2012 Oct;63 (5) :890-7.|[2]Codony X, Vela JM, Ramírez MJ. 5-HT (6) receptor and cognition. Curr Opin Pharmacol. 2011 Feb;11 (1) :94-100.|[3]Maher-Edwards G, Dixon R, Hunter J, et al. SB-742457 and donepezil in Alzheimer disease: a randomized, placebo-controlled study. Int J Geriatr Psychiatry. 2011 May;26 (5) :536-44.|[4]Maher-Edwards G, Zvartau-Hind M, Hunter AJ, et al. Double-blind, controlled phase II study of a 5-HT6 receptor antagonist, SB-742457, in Alzheimer's disease. Curr Alzheimer Res. 2010 Aug;7 (5) :374-85.|[5]Upton N, Chuang TT, Hunter AJ, Virley DJ. 5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease. Neurotherapeutics. 2008 Jul;5 (3) :458-69.|[6]SB-742457
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
5-HT6 Receptor; MUC2
Available Sizes
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