Intepirdine

Intepirdine (SB742457) is a highly selective 5-HT6 receptor antagonist with pKi of 9.63; exhibits >100-fold selectivity over other receptors.

Product Specifications

CAS Number

[607742-69-8]

Product Name Alternative

SB-742457; GSK-742457; RVT-101

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/SB-742457.html

Purity

98.92

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=S(C1=CC=CC=C1)(C2=CC(C=CC=C3N4CCNCC4)=C3N=C2)=O

Molecular Formula

C19H19N3O2S

Molecular Weight

353.44

Precautions

H302, H315, H319, H335

References & Citations

[1]Callaghan CK, Hok V, Della-Chiesa A, et al. Age-related declines in delayed non-match-to-sample performance (DNMS) are reversed by the novel 5HT6 receptor antagonist SB742457. Neuropharmacology. 2012 Oct;63 (5) :890-7.|[2]Codony X, Vela JM, Ramírez MJ. 5-HT (6) receptor and cognition. Curr Opin Pharmacol. 2011 Feb;11 (1) :94-100.|[3]Maher-Edwards G, Dixon R, Hunter J, et al. SB-742457 and donepezil in Alzheimer disease: a randomized, placebo-controlled study. Int J Geriatr Psychiatry. 2011 May;26 (5) :536-44.|[4]Maher-Edwards G, Zvartau-Hind M, Hunter AJ, et al. Double-blind, controlled phase II study of a 5-HT6 receptor antagonist, SB-742457, in Alzheimer's disease. Curr Alzheimer Res. 2010 Aug;7 (5) :374-85.|[5]Upton N, Chuang TT, Hunter AJ, Virley DJ. 5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease. Neurotherapeutics. 2008 Jul;5 (3) :458-69.|[6]SB-742457