IRAK4-IN-6

IRAK4-IN-6 is an orally efficacious and selective IRAK4 inhibitor with an IC50 of 4 nM, and targetes MyD88 L265P mutant diffuse large B cell lymphoma[1].

Product Specifications

CAS Number

[2454244-02-9]

UNSPSC

12352005

Target

IRAK

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/irak4-in-6.html

Purity

99.30

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(N1CCN([C@@H]2CC[C@@H](NC3=C4C(C=CC(CC#N)=N4)=NC(NC5=CN(C)N=C5)=N3)CC2)CC1)OC

Molecular Formula

C25H32N10O2

Molecular Weight

504.59

References & Citations

[1]Degorce SL, et al. Discovery of a Series of 5-Azaquinazolines as Orally Efficacious IRAK4 Inhibitors TargetingMyD88L265P Mutant Diffuse Large B Cell Lymphoma. J Med Chem. 2019 Nov 1.