OF-02
OF-02 is an ionizable lipid for mRNA delivery and a key component of lipid nanoparticles (LNPs) . OF-02 is protonated in the acidic endosomal environment to promote endosomal escape of mRNA and efficiently induce protein expression in target cells. OF-02 relies on the pH-responsive membrane fusion properties to form a complex with mRNA and destroy the endosomal membrane structure to achieve mRNA release in the cytoplasm. OF-02 is mainly used in the development of mRNA vaccines, gene editing, and protein replacement therapy[1][2][3].
Product Specifications
CAS Number
1883431-67-1
UNSPSC
12352005
Hazard Statement
H225, H319
Target
Liposome
Type
Oligonucleotides
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/of-02.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CCCCC/C=C\C/C=C\CCCCCCC(O)CN(CC(O)CCCCCC/C=C\C/C=C\CCCCC)CCCCC1C(NC(C(N1)=O)CCCCN(CC(O)CCCCCC/C=C\C/C=C\CCCCC)CC(O)CCCCCC/C=C\C/C=C\CCCCC)=O
Molecular Formula
C84H152N4O6
Molecular Weight
1314.13
Precautions
H225, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Von Willebrand Factor (3E2D10), CF640R conjugate, 0.1mg/mL
E-Cadherin / CD324 (Intercellular Junction Marker) (4A2), CF594 conjugate, 0.1mg/mL
CD35 / CR1 (E11), CF405S conjugate, 0.1mg/mL
CD50 (ICAM-3) (186-2G9), CF568 conjugate, 0.1mg/mL
CD81 / TAPA-1 (1.3.3.22), CF405S conjugate, 0.1mg/mL
