AGN 193109-d7

AGN 193109-d7 is the deuterium labeled AGN 193109. AGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of retinoic acid receptors (RARs), with Kds of 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ, respectively.

Product Specifications

CAS Number

[1216429-25-2]

UNSPSC

12352005

Target

Isotope-Labeled Compounds; RAR/RXR

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

Field of Research

Cancer

Solubility

10 mM in DMSO

Smiles

CC1(C2=C(C(C3=C(C([2H])=C(C([2H])=C3[2H])C([2H])([2H])[2H])[2H])=CC1)C=C(C=C2)C#CC4=CC=C(C=C4)C(O)=O)C

Molecular Formula

C28H17D7O2

Molecular Weight

399.53

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Johnson AT, et al. Synthesis and characterization of a highly potent and effective antagonist of retinoic acid receptors. J Med Chem. 1995 Nov 24;38 (24) :4764-7.|[3]Agarwal C, et al. AGN193109 is a highly effective antagonist of retinoid action in human ectocervical epithelial cells. J Biol Chem. 1996 May 24;271 (21) :12209-12.|[4]Standeven AM, et al. Specific antagonist of retinoid toxicity in mice. Toxicol Appl Pharmacol. 1996 May;138 (1) :169-75.