Nevirapine

Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a Ki of 270 μM[1].

Product Specifications

CAS Number

[129618-40-2]

Product Name Alternative

BI-RG 587; NSC 641530; NVP

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

HIV; Parasite; Reverse Transcriptase

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/Nevirapine.html

Purity

99.93

Solubility

DMSO : 14.29 mg/mL (ultrasonic)

Smiles

O=C1C2=C(N=CC=C2)N(C3CC3)C4=NC=CC(C)=C4N1

Molecular Formula

C15H14N4O

Molecular Weight

266.30

Precautions

H302, H315, H319, H335

References & Citations

[1]Erickson DA, et al. Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitornevirapine by human hepatic cytochromes P-450. Drug Metab Dispos. 1999 Dec;27 (12) :1488-95.|[2]Dong JJ, et al. In vitro evaluation of the therapeutic potential of nevirapine in treatment of human thyroid anaplastic carcinoma. Mol Cell Endocrinol. 2013 May 6;370 (1-2) :113-8.|[3]Merluzzi VJ, et al. Inhibition of HIV-1 replication by a nonnucleoside reverse transcriptase inhibitor. Science. 1990 Dec 7;250 (4986) :1411-3.|[4]Riska PS, et al. Biotransformation of nevirapine, a non-nucleoside HIV-1 reverse transcriptase inhibitor, in mice, rats, rabbits, dogs, monkeys, and chimpanzees. Drug Metab Dispos. 1999 Dec;27 (12) :1434-47.|[5]Onasanwo SA, et al. Evaluation of anti-ulcerogenic and ulcer-healing activities of nevirapine in rats. Afr J Med Med Sci. 2015 Sep;44 (3) :251-9.