Nevirapine
Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a Ki of 270 μM[1].
Product Specifications
CAS Number
129618-40-2
Product Name Alternative
BI-RG 587; NSC 641530; NVP
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
HIV; Parasite; Reverse Transcriptase
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/Nevirapine.html
Purity
99.93
Solubility
DMSO : 14.29 mg/mL (ultrasonic)
Smiles
O=C1C2=C(N=CC=C2)N(C3CC3)C4=NC=CC(C)=C4N1
Molecular Formula
C15H14N4O
Molecular Weight
266.30
Precautions
H302, H315, H319, H335
References & Citations
[1]Erickson DA, et al. Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitornevirapine by human hepatic cytochromes P-450. Drug Metab Dispos. 1999 Dec;27 (12) :1488-95.|[2]Dong JJ, et al. In vitro evaluation of the therapeutic potential of nevirapine in treatment of human thyroid anaplastic carcinoma. Mol Cell Endocrinol. 2013 May 6;370 (1-2) :113-8.|[3]Merluzzi VJ, et al. Inhibition of HIV-1 replication by a nonnucleoside reverse transcriptase inhibitor. Science. 1990 Dec 7;250 (4986) :1411-3.|[4]Riska PS, et al. Biotransformation of nevirapine, a non-nucleoside HIV-1 reverse transcriptase inhibitor, in mice, rats, rabbits, dogs, monkeys, and chimpanzees. Drug Metab Dispos. 1999 Dec;27 (12) :1434-47.|[5]Onasanwo SA, et al. Evaluation of anti-ulcerogenic and ulcer-healing activities of nevirapine in rats. Afr J Med Med Sci. 2015 Sep;44 (3) :251-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
HIV-1
Available Sizes
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