GB-110 (hydrochloride)

GB-110 hydrochloride is a potent, orally active, and nonpeptidic protease activated receptor 2 (PAR2) agonist. GB-110 hydrochloride selectively induces PAR2-mediated intracellular Ca2+ release in HT29 cells with an EC50 of 0.28 μM[1].

Product Specifications

UNSPSC

12352005

Target

Protease Activated Receptor (PAR)

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/gb-110-hydrochloride.html

Purity

99.86

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=NO1)N[C@@H](CC2CCCCC2)C(N[C@@H]([C@@H](C)CC)C(NCC3=CC=CC(C(N4CCC(CN)CC4)=O)=C3)=O)=O.Cl

Molecular Formula

C33H49ClN6O5

Molecular Weight

645.23

References & Citations

[1]Barry GD, et al. Novel agonists and antagonists for human protease activated receptor 2. J Med Chem. 2010 Oct 28;53 (20) :7428-40.|[2]Suen JY, et al. Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110) . Br J Pharmacol. 2012 Mar;165 (5) :1413-23.