(E/Z) -IT-603

(E/Z) -IT-603 is a mixture of E-IT-603 and Z-IT-603 (IT-603) . (E/Z) -IT-603 is also an IĸBα/c-Rel inhibitor. IT-603 is a c-Rel inhibitor with an IC50 of 3 μM. IT-603 has anti-tumor activity. (E/Z) -IT-603 is a promising modulator of T-cell responses in the context of graft-versus-host disease (GVHD) and malignant diseases[1].

Product Specifications

CAS Number

[292168-90-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

NF-κB

Type

Reference compound

Related Pathways

NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/e-z-it-603.html

Purity

99.91

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(/C(N1)=C\C2=CC(Br)=CC(OC)=C2O)NC1=S

Molecular Formula

C11H9BrN2O3S

Molecular Weight

329.17

Precautions

H302, H315, H319, H335

References & Citations

[1]Yusuke Shono, et al. A small molecule c-Rel inhibitor reduces alloactivation of T-cells without compromising anti-tumor activity. Cancer Discov. 2014 May; 4 (5) : 578-591.|[2]Huang X, et al. ESAT-6 protein suppresses allograft rejection by inducing CD4+Foxp3+ regulatory T cells through IκBα/cRel pathway. Front Immunol. 2025 Jan 9;15:1529226.