What is the catalog number for Anti-Hu CD8 Pacific Blue™?

The catalog number for Anti-Hu CD8 Pacific Blue™ is PB-817-T100.

What sizes are available for Anti-Hu CD8 Pacific Blue™?

Anti-Hu CD8 Pacific Blue™ is available in the following size(s): 100 Tests.

Is Anti-Hu CD8 Pacific Blue™ in stock?

Anti-Hu CD8 Pacific Blue™ is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Anti-Hu CD8 Pacific Blue™?

Anti-Hu CD8 Pacific Blue™ is manufactured by AFG-XBO.

What is the estimated delivery time for Anti-Hu CD8 Pacific Blue™?

Estimated delivery time for Anti-Hu CD8 Pacific Blue™ is approximately 10 business day(s), depending on your location.

Anti-Hu CD8 Pacific Blue™

The CD8 T cell coreceptor (monomer approx. 32-34 kDa) is expressed as alpha/beta heterodimer on majority of MHC I-restricted conventional T cells and thymocytes and as alpha/alpha homodimer on subsets of memory T cells, intraepithelial lymphocytes, NK cells and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha-beta but not alpha-alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.

Product Specifications

Certification

RUO

Reactivity

Non-human primates, Human

Immunogen

Human blood lymphocytes

Target Antigen

CD8

Clone

LT8

Applications

FC (QC tested)

Format

Pacific Blue

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Ivanidze J, Hoffmann R, Lochmüller H, Engel AG, Hohlfeld R, Dornmair K: Inclusion body myositis: laser microdissection reveals differential up-regulation of IFN-γ signaling cascade in attacked versus nonattacked myofibers. Am J Pathol. 2011 Sep;179 (3) :1347-59., URL: https://pubmed.ncbi.nlm.nih.gov/21855683/, *Agea E, Russano A, Bistoni O, Mannucci R, Nicoletti I, Corazzi L, Postle AD, De Libero G, Porcelli SA, Spinozzi F: Human CD1-restricted T cell recognition of lipids from pollens. J Exp Med. 2005 Jul 18;202 (2) :295-308., URL: https://www.ncbi.nlm.nih.gov/pubmed/16009719, *Held K, Bhonsle-Deeng L, Siewert K, Sato W, Beltrán E, Schmidt S, Rühl G, Ng JK, Engerer P, Moser M, Klinkert WE, Babbe H, Misgeld T, Wekerle H, Laplaud DA, Hohlfeld R, Dornmair K: αβ T-cell receptors from multiple sclerosis brain lesions show MAIT cell-related features. Neurol Neuroimmunol Neuroinflamm. 2015 May 7;2 (4) :e107., URL: https://www.ncbi.nlm.nih.gov/pubmed/25977934 Ivani, *Nelson M, Loveday M: Exploring the innate immunological response of an alternative nonhuman primate model of infectious disease; the common marmoset. J Immunol Res. 2014;2014:913632., URL: https://www.ncbi.nlm.nih.gov/pubmed/?term=m+nelson+m+loveday Agea E Russano A Bistoni O Mannucci R Nicoletti I Corazzi L Postle AD De Libero G Porcelli SA Spinozzi F: Human CD1-restricted T cell recognition of lipids from pollens. J Exp Med. 2005 Jul

Other References

*Devine L, Thakral D, Nag S, Dobbins J, Hodsdon ME, Kavathas PB: Mapping the binding site on CD8 beta for MHC class I reveals mutants with enhanced binding. J Immunol. 2006 Sep 15;177 (6) :3930-8., URL: https://pubmed.ncbi.nlm.nih.gov/16951356/, *Pang DJ, Hayday AC, Bijlmakers MJ: CD8 Raft localization is induced by its assembly into CD8alpha beta heterodimers, not CD8alpha alpha homodimers. J Biol Chem. 2007 May 4;282 (18) :13884-94., URL: https://pubmed.ncbi.nlm.nih.gov/17341584/, *van den Berg HA, Wooldridge L, Laugel B, Sewell AK: Coreceptor CD8-driven modulation of T cell antigen receptor specificity. J Theor Biol. 2007 Nov 21;249 (2) :395-408., URL: https://pubmed.ncbi.nlm.nih.gov/17869274/

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The mouse monoclonal antibody LT8 recognizes an extracellular epitope of CD8, a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. This antibody blocks Leu2 binding.