What is the catalog number for Anti-Hu CD52 PE?

The catalog number for Anti-Hu CD52 PE is 1P-878-T100.

What sizes are available for Anti-Hu CD52 PE?

Anti-Hu CD52 PE is available in the following size(s): 100 Tests.

Is Anti-Hu CD52 PE in stock?

Anti-Hu CD52 PE is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Anti-Hu CD52 PE?

Anti-Hu CD52 PE is manufactured by AFG-XBO.

What is the estimated delivery time for Anti-Hu CD52 PE?

Estimated delivery time for Anti-Hu CD52 PE is approximately 10 business day(s), depending on your location.

Anti-Hu CD52 PE

CD52 (CAMPATH-1, HE5) is a highly glycosylated GPI-anchored 21-28 kDa glycopeptide which is present at high levels on lymphocytes, macrophages, epithelial cells of male reproductive tract and mature sperm. Its 12-amino acid beckbone carries a complex N-linked carbohydrate moiety, which differs between sperm and leukocyte CD52, as well as the GPI anchor does. CD52 can be acquired by sperm cells from seminal plasma, where it is released by epithelial cells. Although CD52 is not an essential T-cell costimulator, its triggering results in activation of normal human T cells. CD52 is a very good target for antibody/complement-mediated cell lysis.

Product Specifications

Certification

RUO

Reactivity

Human

Immunogen

Human lymphocytes

Target Antigen

CD52

Clone

4C8

Applications

FC (QC tested)

Format

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Masuyama J, Kaga S, Kano S, Minota S: A novel costimulation pathway via the 4C8 antigen for the induction of CD4+ regulatory T cells. J Immunol. 2002 Oct 1;169 (7) :3710-6., URL: https://pubmed.ncbi.nlm.nih.gov/12244164/?from_term=masuyama+kaga+&from_pos=4 , *Masuyama J, Yoshio T, Suzuki K, Kitagawa S, Iwamoto M, Kamimura T, Hirata D, Takeda A, Kano S, Minota S: Characterization of the 4C8 antigen involved in transendothelial migration of CD26 (hi) T cells after tight adhesion to human umbilical vein endothelial cell monolayers. J Exp Med. 1999 Mar 15;189 (6) :979-90., URL: https://pubmed.ncbi.nlm.nih.gov/10075981/?from_term=masuyama+yoshio+suzuki&from_schema=all&from_pos=3, *Toh BH, Kyaw T, Tipping P, Bobik A: Immune Regulation by CD52-expressing CD4 T Cells. Cell Mol Immunol. 2013 Sep;10 (5) :379-82., URL: https://pubmed.ncbi.nlm.nih.gov/23934027/?from_term=tipping+p+bobik+a+kyaw&from_page=2&from_pos=6, *Watanabe T, Masuyama J, Sohma Y, Inazawa H, Horie K, Kojima K, Uemura Y, Aoki Y, Kaga S, Minota S, Tanaka T, Yamaguchi Y, Kobayashi T, Serizawa I: CD52 is a novel costimulatory molecule for induction of CD4+ regulatory T cells. Clin Immunol. 2006 Sep;120 (3) :247-59., URL: https://pubmed.ncbi.nlm.nih.gov/16797237/?from_term=watanabe+inazawa&from_page=2&from_pos=7

Other References

*Schröter S, Derr P, Conradt HS, Nimtz M, Hale G, Kirchhoff C: Male-specific modification of human CD52. J Biol Chem. 1999 Oct 15;274 (42) :29862-73., URL: https://www.ncbi.nlm.nih.gov/pubmed/10514467?ordin, *Treumann A, Lifely MR, Schneider P, Ferguson MA: Primary structure of CD52. J Biol Chem. 1995 Mar 17;270 (11) :6088-99. , URL: https://www.ncbi.nlm.nih.gov/pubmed/7890742?ordina, *Rowan WC, Hale G, Tite JP, Brett SJ: Cross-linking of the CAMPATH-1 antigen (CD52) triggers activation of normal human T lymphocytes. Int Immunol. 1995 Jan;7 (1) :69-77., URL: https://www.ncbi.nlm.nih.gov/pubmed/7718516?ordina, *Koyama K, Ito K, Hasegawa A: Role of male reproductive tract CD52 (mrt-CD52) in reproduction. Soc Reprod Fertil Suppl. 2007;63:103-10., URL: https://www.ncbi.nlm.nih.gov/pubmed/17566265?ordin, *Domagała A, Kurpisz M: CD52 antigen--a review. Med Sci Monit. 2001 Mar-Apr;7 (2) :325-31., URL: https://www.ncbi.nlm.nih.gov/pubmed/11257744?ordin

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The mouse monoclonal antibody 4C8 recognizes CD52, a GPI-anchored glycopeptide expressed on the surface of lymphocytes, macrophages, epithelial cells of male reproductive tract, and mature sperms.