What is the catalog number for Anti-TNAP PE?

The catalog number for Anti-TNAP PE is 1P-831-C100.

What sizes are available for Anti-TNAP PE?

Anti-TNAP PE is available in the following size(s): 0.1 mg.

Is Anti-TNAP PE in stock?

Anti-TNAP PE is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Anti-TNAP PE?

Anti-TNAP PE is manufactured by AFG-XBO.

What is the estimated delivery time for Anti-TNAP PE?

Estimated delivery time for Anti-TNAP PE is approximately 10 business day(s), depending on your location.

Anti-TNAP PE

Tissue non-specific alkaline phosphatase (TNAP), also known as liver/bone/kidney alkaline phosphatase, or MSCA-1 (mesenchymal stem cell antigen 1) is a selective marker for the prospective isolation of bone marrow-derived mesenchymal stem cells and mesenchymal stem-like cells. It is expressed at high levels in liver, bone, kidney, or endometrium, as well as on embryonic stem cells (ESCs) . TNAP also plays a role in bone mineralization. Mutations in TNAP gene are associated with hypercalcemia and skeletal defects (hypophosphatasia) .

Product Specifications

Certification

RUO

Reactivity

Dog, Pig, Sheep, Monkey, Goat, Human

Immunogen

WERI-RB-1 retinoblastoma cell line

Target Antigen

TNAP

Clone

W8B2B10

Applications

FC (QC tested)

Concentration

0.1 mg/mL

Format

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Vogel W, Grünebach F, Messam CA, Kanz L, Brugger W, Bühring HJ: Heterogeneity among human bone marrow-derived mesenchymal stem cells and neural progenitor cells. Haematologica. 2003 Feb;88 (2) :126-33., URL: https://pubmed.ncbi.nlm.nih.gov/12604402/, *Bühring HJ, Battula VL, Treml S, Schewe B, Kanz L, Vogel W: Novel markers for the prospective isolation of human MSC. Ann N Y Acad Sci. 2007 Jun;1106:262-71. , URL: https://www.ncbi.nlm.nih.gov/pubmed/17395729, *Sobiesiak M, Sivasubramaniyan K, Hermann C, Tan C, Orgel M, Treml S, Cerabona F, de Zwart P, Ochs U, Müller CA, Gargett CE, Kalbacher H, Bühring HJ: The mesenchymal stem cell antigen MSCA-1 is identical to tissue non-specific alkaline phosphatase. Stem Cells Dev. 2010 May;19 (5) :669-77., URL: https://www.ncbi.nlm.nih.gov/pubmed/19860546, *Rozemuller H, Prins HJ, Naaijkens B, Staal J, Bühring HJ, Martens AC: Prospective isolation of mesenchymal stem cells from multiple mammalian species using cross-reacting anti-human monoclonal antibodies. Stem Cells Dev. 2010 Dec;19 (12) :1911-21., URL: https://www.ncbi.nlm.nih.gov/pubmed/20367498

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The mouse monoclonal antibody W8B2B10 recognizes TNAP (tissue non-specific alkaline phosphatase), an ectoenzyme expressed mainly on embryonic stem cells, liver, bone, and kidney cells. This antibody is suitable for characterization of bone marrow-derived MSCs, iPSCs, and ESCs.