EN219
EN219 is a moderately selective synthetic covalent ligand against an N-terminal cysteine (C8) of RNF114 with an IC50 of 470 nM. EN219 inhibits RNF114-mediated autoubiquitination and p21 ubiquitination[1].
Product Specifications
CAS Number
[380351-29-1]
Product Name Alternative
CD5789
UNSPSC
12352005
Hazard Statement
H301, H311, H331, H341
Target
E1/E2/E3 Enzyme
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/en219.html
Purity
99.21
Solubility
DMSO : 65 mg/mL (ultrasonic)
Smiles
ClCC(N1N=C(C2=CC=C(Br)C=C2)CC1C3=CC=C(Br)C=C3)=O
Molecular Formula
C17H13Br2ClN2O
Molecular Weight
456.56
Precautions
H301, H311, H331, H341
References & Citations
[1]Luo M, et al. Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function. Cell Chem Biol. 2021 Apr 15;28 (4) :559-566.e15.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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