EN219
Product Specifications
Product Name Alternative
CD5789
UNSPSC Description
EN219 is a moderately selective synthetic covalent ligand against an N-terminal cysteine (C8) of RNF114 with an IC50 of 470 nM. EN219 inhibits RNF114-mediated autoubiquitination and p21 ubiquitination[1].
Target Antigen
E1/E2/E3 Enzyme
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/en219.html
Purity
98.56
Solubility
DMSO : 65 mg/mL (ultrasonic)
Smiles
ClCC(N1N=C(C2=CC=C(Br)C=C2)CC1C3=CC=C(Br)C=C3)=O
Molecular Weight
456.56
References & Citations
[1]Luo M, et al. Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function. Cell Chem Biol. 2021 Apr 15;28(4):559-566.e15.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-115715/EN219-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-115715/EN219-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
380351-29-1
Available Sizes
Curated Selection
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