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EN219

EN219 is a moderately selective synthetic covalent ligand against an N-terminal cysteine (C8) of RNF114 with an IC50 of 470 nM. EN219 inhibits RNF114-mediated autoubiquitination and p21 ubiquitination[1].

Product Specifications

CAS Number

380351-29-1

Product Name Alternative

CD5789

UNSPSC

12352005

Hazard Statement

H301, H311, H331, H341

Target

E1/E2/E3 Enzyme

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/en219.html

Purity

99.21

Solubility

DMSO : 65 mg/mL (ultrasonic)

Smiles

ClCC(N1N=C(C2=CC=C(Br)C=C2)CC1C3=CC=C(Br)C=C3)=O

Molecular Formula

C17H13Br2ClN2O

Molecular Weight

456.56

Precautions

H301, H311, H331, H341

References & Citations

[1]Luo M, et al. Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function. Cell Chem Biol. 2021 Apr 15;28 (4) :559-566.e15.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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