Anti-Hu CD93 FITC

CD93 (also known as C1qR1) is a type I transmembrane glycoprotein containing extracellular N-terminal C-type lectin domain and five EGF-like domains, and an intracellular tail interacting with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton. CD93 was reported to serve as a receptor for complement component C1q, but this function has not been fully elucidated yet. CD93 is involved in intercellular adhesion and in the clearance of apoptotic cells.

Product Specifications

Certification

RUO

Reactivity

Human

Immunogen

KG1 cell line

Target Antigen

CD93

Clone

VIMD2

Applications

FC (QC tested)

Format

FITC

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Steinberger P, Szekeres A, Wille S, Stöckl J, Selenko N, Prager E, Staffler G, Madic O, Stockinger H, Knapp W: Identification of human CD93 as the phagocytic C1q receptor (C1qRp) by expression cloning. J Leukoc Biol. 2002 Jan;71 (1) :133-40., URL: http://www.ncbi.nlm.nih.gov/pubmed/11781389

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The mouse monoclonal antibody VIMD2 recognizes an extracellular epitope on CD93, an approximately 110-120 kDa glycoprotein expressed mainly on myeloid cells and endothelial cells.